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KMID : 0359919920110040477
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Korean Journal of Nephrology
1992 Volume.11 No. 4 p.477 ~ p.481
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Two Cases of Acute Renal Failure in Paroxysmal Nocturnal Hemoglobinuria
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김선숙
이영호/연종은/안정천/신상원/차대룡/권영주/조원용/김준석
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Abstract
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Paroxysmal nocturnal hemoglobinuria is an uncommon acquired disease of unknown etiology characterized by recurrent chronic hemolytic anemia and thrombosis. Rarely acute renal failure may occur. The pathogenesis of acute renal failure in PNH is
not
well
understood.
We experienced two cases, which were shown acute renal failure and hemolytic anemia as first manifestation and then diagnosed as PNH by Ham's test. These patients might be progressed acute renal failure by hemolytic crisis associated with
aggravating
factors such as dehydration, hypotension, and renal ischemia.
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KEYWORD
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